Description
Enalapril maleate : Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE). The mechanism through which enalapril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. In patients treated with enalapril maleate plus a thiazide diuretic, there was essentially no change in serum potassium. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. It affects the distal renal tubular mechanism of electrolyte reabsorption. Hydrochlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.
Additional information
| brand | Nabiqasim Industries |
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