Description
Buspirone is a member of the azapirone class of drugs. It has anxiolytic activity, but is largely lacking in sedative and muscle relaxant effects and anticonvulsant activity. Its mechanism of action has yet to be fully explained. Evidence to date suggests that its activity is based on its effects on serotonin (5-HT) receptors. It acts as an agonist of pre-synaptic and partial agonist of post-synaptic 5-HT1A subtype receptors. It is thought this initiates long-term changes in central 5-HT neurotransmission, producing the efficacy seen in the treatment of anxiety. Buspirone is thought to have antagonist activity at D2 receptors at the doses stipulated for anxious disorders, though it is unclear if this is linked to its anxiolytic activity. Buspirone’s effects on GABAergic mechanisms are unclear. It does not directly interact with either the benzodiazepine-GABA receptor complex or GABA receptors. However, there is indirect evidence for buspirone having a GABA antagonist-like action.
Additional information
| brand | S.J. & G. FAZIL ELLAHIE |
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